Research
In my roles as a faculty biostatistician at Case particularly at Case
Comprehensive Cancer Center,
I have led since 2001 among other things the design and implementation
and analysis of numerous clinical trial studies for many therapeutic
development areas. We developed a novel design taking population enrichment by
tumor growth characteristics into consideration, conducted systemtic reviewes
on phase 1 trials with and without expansion cohort, and have implemented many
novel designs in early phase (1 and 2) clinical trials.
The content areas of my research interests cover cancer, HIV/AIDS,
dermatology and behavior problems in children among others. My primary
interests in these areas include providing advice for researchers
in terms of study design, the best practice for estimation, inference,
diagnostics, and use of appropriate statistical methods to analyze the complex
data from pre-clinical and clinical studies.
My methodologic research interests are in the areas of survival analysis,
study design, research synthesis, measurements with limits of detection,
tree-based methods, problem of separation and copula models to estimate the
correlation of bivariate failure times.
Publications